Natural rubber (NR) is primarily obtained from Hevea brasiliensis, commonly known as the Brazilian rubber tree. As this species contains little genetic variation, it is susceptible to pathogen-based eradication. Consequently, it is imperative that a biomimetic pathway for NR production be developed. Puskas et al. recently proposed that NR biosynthesis proceeds via a carbocationic polymerization mechanism. Based on this theory, a general mechanism termed “Natural Living Carbocationic Polymerization” (NLCP) was developed.