Guayule, Parthenium argentatum, latex is commercially available as an alternate rubber source (Yulex® latex) and is currently the sole U.S. natural rubber of domestic origin. It is the worlds first natural rubber latex that is safe for Type 1 latex allergy sufferers due to the fact that it lacks proteins that cross-react with Hevea latex antigenic proteins. Also, Yulex® latex provides superior product performance. In this paper, the use and performance of Yulex® Latex in various medical devices will be discussed. In addition, guayule latex product performance is compared against Hevea NRL and various synthetics.