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Video: ExxonMobil exec says innovation is key to growth
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BEACHWOOD, Ohio—An ExxonMobil official painted a bright future for the rubber industry as long as the key players along the entire value chain focus on innovation and the factors driving...
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BEACHWOOD, Ohio—An ExxonMobil official painted a bright future for the rubber industry as long as the key players along the entire value chain focus on innovation and the factors driving rising demand. BEACHWOOD, Ohio—An ExxonMobil official painted a bright future for the rubber industry as long as the key players along the entire value chain focus on innovation and the factors driving rising demand. $BEACHWOOD, Ohio—An ExxonMobil official painted a bright future for the rubber industry as long as the key players along the entire value chain focus on innovation and the factors driving rising demand.
Degenhart: Conti to keep its balance amid high-tech shift
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HANOVER, Germany—Continental A.G. will maintain the position of rubber-based businesses within the group even as it moves to become a leading player in the field of autonomous and connected...
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HANOVER, Germany—Continental will maintain the position of rubber-based businesses within the group even as it moves to become a leading player in the field of autonomous and connected vehicle technologies, according to CEO Elmar Degenhart. HANOVER, Germany—Continental will maintain the position of rubber-based businesses within the group even as it moves to become a leading player in the field of autonomous and connected vehicle technologies, according to CEO Elmar Degenhart. $HANOVER, Germany—Continental will maintain the position of rubber-based businesses within the group even as it moves to become a leading player in the field of autonomous and connected vehicle technologies, according to CEO Elmar Degenhart.
ContiTech expands elevator belt production in Germany
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DANNENBERG, Germany—ContiTech A.G. has expanded its production of elevator belts at its site in Dannenberg to meet growing demand. With a $5.58 million investment, the company has added a...
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DANNENBERG, Germany—ContiTech has expanded its production of elevator belts at its site in Dannenberg to meet growing demand. DANNENBERG, Germany—ContiTech has expanded its production of elevator belts at its site in Dannenberg to meet growing demand. $DANNENBERG, Germany—ContiTech has expanded its production of elevator belts at its site in Dannenberg to meet growing demand.
Bridgestone invests in proactive ride technology
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NASHVILLE, Tenn.—Bridgestone Americas Inc. invested in ClearMotion Inc. a venture-backed technology company developing road-sensing software and hardware that dramatically improves ride...
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NASHVILLE, Tenn.—Bridgestone Americas invested in ClearMotion, a venture-backed technology company developing road-sensing software and hardware that dramatically improves ride performance in cars. NASHVILLE, Tenn.—Bridgestone Americas invested in ClearMotion, a venture-backed technology company developing road-sensing software and hardware that dramatically improves ride performance in cars. $NASHVILLE, Tenn.—Bridgestone Americas invested in ClearMotion, a venture-backed technology company developing road-sensing software and hardware that dramatically improves ride performance in cars.
Sonus follows same path with new name
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WARREN, Mich.—Sonus Engineered Solutions may have a new name, but its mission remains the same. The formerly-named Novo Motor Acoustic Systems Inc., a supplier of automotive parts designed...
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WARREN, Mich.—Sonus Engineered Solutions may have a new name, but its mission remains the same. WARREN, Mich.—Sonus Engineered Solutions may have a new name, but its mission remains the same. $WARREN, Mich.—Sonus Engineered Solutions may have a new name, but its mission remains the same.
Michelin unveils 'Vision' for future
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MONTREAL—A new vision for sustainable mobility in the future, underscored by a new logo, was the big reveal for Michelin at its Movin' On 2017 conference in Montreal June 13-15.Michelin's...
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MONTREAL—A new vision for sustainable mobility in the future, underscored by a new logo, was the big reveal for Michelin at its Movin' On 2017 conference in Montreal June 13-15. MONTREAL—A new vision for sustainable mobility in the future, underscored by a new logo, was the big reveal for Michelin at its Movin' On 2017 conference in Montreal June 13-15. $MONTREAL—A new vision for sustainable mobility in the future, underscored by a new logo, was the big reveal for Michelin at its Movin' On 2017 conference in Montreal June 13-15.
Smithers breaks ground on laboratory expansion
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RAVENNA, Ohio—Independent, third-party laboratory Smithers Rapra broke ground recently on a new expansion at the Smithers Tire and Wheel Test Center in Ravenna. Six of the top global tire...
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RAVENNA, Ohio—Smithers Rapra broke ground on a new expansion at the Smithers Tire and Wheel Test Center in Ravenna. RAVENNA, Ohio—Smithers Rapra broke ground on a new expansion at the Smithers Tire and Wheel Test Center in Ravenna. $RAVENNA, Ohio—Smithers Rapra broke ground on a new expansion at the Smithers Tire and Wheel Test Center in Ravenna.
Wacker opens silicones R&D center in Mich.
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ANN ARBOR, Mich.—Wacker Chemie A.G. has opened its Silicones R&D Center in Ann Arbor that will be used to develop new products for its customers in the Americas. The 10,000-sq.-ft. site ...
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ANN ARBOR, Mich.—Wacker Chemie has opened its Silicones R&D Center in Ann Arbor that will be used to develop new products for its customers in the Americas. ANN ARBOR, Mich.—Wacker Chemie has opened its Silicones R&D Center in Ann Arbor that will be used to develop new products for its customers in the Americas. $ANN ARBOR, Mich.—Wacker Chemie has opened its Silicones R&D Center in Ann Arbor that will be used to develop new products for its customers in the Americas.
Online extra: New fire hose addresses kink-resistant trend
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SAN ANTONIO—One trend on the municipal side of the fire hose market has been toward lower-pressure nozzles to help fight such issues as firefighter fatigue. And while much development work...
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SAN ANTONIO—North American Fire Hose recently introduced a highly kink-resistant fire hose that will work at lower pressure. It's part of an industry trend toward lower-pressures and nozzles which help fight such issues as firefighter fatigue. SAN ANTONIO—North American Fire Hose recently introduced a highly kink-resistant fire hose that will work at lower pressure. It's part of an industry trend toward lower-pressures and nozzles which help fight such issues as firefighter fatigue. $SAN ANTONIO—North American Fire Hose recently introduced a highly kink-resistant fire hose that will work at lower pressure. It's part of an industry trend toward lower-pressures and nozzles which help fight such issues as firefighter fatigue.
New challenges, uncertainty on horizon for automotive industry
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ANN ARBOR, Mich.—The automotive industry has dug itself out of the Great Recession, but there's plenty of uncertainty on the horizon. Light vehicle sales in the U.S. have grown every year...
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ANN ARBOR, Mich.—The automotive industry has dug itself out of the Great Recession, but there's plenty of uncertainty on the horizon. ANN ARBOR, Mich.—The automotive industry has dug itself out of the Great Recession, but there's plenty of uncertainty on the horizon. $ ANN ARBOR, Mich.—The automotive industry has dug itself out of the Great Recession, but there's plenty of uncertainty on the horizon.
Digital Edition
Digital Edition
Published on January 1, 2009

Characteristics of Rubber Used in Pharmaceuticals

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Date Published January 1, 2009
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This Report has been authored by:Fran L. DeGrazio at West PharmaceuticalServices Inc. #with# Jim Castner at Lantheus Medical Imaging #with# Wai Keung Wong at ExxonMobil Chemical Europe #with# Dennis Jenke at Baxter Healthcare Corp. #with# Daniel L. Norwood at Boehringer Ingelheim Pharmaceutics,” says Scheumann. Jason fpICC

Rubber materials are widely used in systems used to manufacture, package and deliver pharmaceutical products. While the rubber material’s nature and composition gives it its necessary and desirable performance characteristics, these material properties can have important and potentially detrimental consequences for the pharmaceutical products. Interactions between these materials and the pharmaceutical products they contact are well known and documented and can result in a change in the product’s composition, which may adversely affect product safety (e.g., the product produces an unanticipated and adverse user response) and/or efficacy (e.g., the product performs in a manner inconsistent with its labeling and indication). Therefore, rubber materials used in pharmaceutical products must be evaluated to determine what material components can, and do, migrate from the materials and accumulate in the pharmaceutical product, as it is through the presence and actions of such substances that product safety and/or efficacy may be compromised.

The characterization of materials for their extractables (substances that can migrate) and of products for their leachables (substances that do accumulate) is a necessary and complex part of the development, registration and manufacturing and distribution and therapeutic products.

This manuscript provides a general overview of the extractables and leachables issues associated with materials used with/in therapeutic products. 

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