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Datwyler opens Delaware plant
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MIDDLETOWN, Del.—The sealing unit of Datwyler Holding A.G. celebrated the grand opening of its new medical manufacturing plant in Middletown. The site represents a $100 million investment,...
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MIDDLETOWN, Del.—The sealing unit of Datwyler Holding celebrated the grand opening of its new medical manufacturing plant in Middletown. MIDDLETOWN, Del.—The sealing unit of Datwyler Holding celebrated the grand opening of its new medical manufacturing plant in Middletown. $MIDDLETOWN, Del.—The sealing unit of Datwyler Holding celebrated the grand opening of its new medical manufacturing plant in Middletown.
Yokohama to combine R&D efforts into new center
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CORNELIUS, N.C.—Yokohama Tire Corp. has opened a new research and development facility in Cornelius, designed to bring together its R&D efforts into one location.Yokohama Development...
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CORNELIUS, N.C.—Yokohama has opened a new research and development facility in Cornelius, designed to bring together its research and development efforts into one location. CORNELIUS, N.C.—Yokohama has opened a new research and development facility in Cornelius, designed to bring together its research and development efforts into one location. $CORNELIUS, N.C.—Yokohama has opened a new research and development facility in Cornelius, designed to bring together its research and development efforts into one location.
Photos: Goodyear tires drive NASCAR tradition
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AKRON—The first thing you sense while you tour the Goodyear Innovation Center Manufacturing facility in Akron is the enormous amount of pride, workmanship and know-how that goes into each of ...
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AKRON—The first thing you sense while you tour the Goodyear Innovation Center Manufacturing facility in Akron is the enormous amount of pride, workmanship and know-how that goes into each of the 4,000-plus racing tires. AKRON—The first thing you sense while you tour the Goodyear Innovation Center Manufacturing facility in Akron is the enormous amount of pride, workmanship and know-how that goes into each of the 4,000-plus racing tires. $AKRON—The first thing you sense while you tour the Goodyear Innovation Center Manufacturing facility in Akron is the enormous amount of pride, workmanship and know-how that goes into each of the 4,000-plus racing tires.
Electrification shaking up rubber auto parts sector
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Electrification is shaking up the automotive parts supply-chain: forcing rubber product companies to add new capabilities to their established areas of expertise in materials science and...
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Electrification is shaking up the automotive parts supply-chain: forcing rubber product companies to add new capabilities to their established areas of expertise in materials science and technology. Electrification is shaking up the automotive parts supply-chain: forcing rubber product companies to add new capabilities to their established areas of expertise in materials science and technology. $Electrification is shaking up the automotive parts supply-chain: forcing rubber product companies to add new capabilities to their established areas of expertise in materials science and technology.
Evonik opens tire silicas plant in South Carolina
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GOOSE CREEK, S.C.—Evonik Industries has inaugurated a precipitated silica plant in South Carolina, aimed at better serving the U.S. tire industry.The $120 million investment comes in...
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GOOSE CREEK, S.C.—Evonik Industries has inaugurated a precipitated silica plant in South Carolina, aimed at better serving the U.S. tire industry. GOOSE CREEK, S.C.—Evonik Industries has inaugurated a precipitated silica plant in South Carolina, aimed at better serving the U.S. tire industry. $GOOSE CREEK, S.C.—Evonik Industries has inaugurated a precipitated silica plant in South Carolina, aimed at better serving the U.S. tire industry.
Long development journey pays off for Tweel, Michelin
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AKRON—For the record, Michelin's Steve Cron isn't a big fan of the name given to the product that has defined much of his 30-year career in the tire industry. That product is the Tweel, the ...
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AKRON—For the record, Michelin's Steve Cron isn't a big fan of the name given to the product that has defined much of his 30-year career in the tire industry. That product is the Tweel, the tire maker's easily recognizable product that combines a non-pneumatic tire with a polyurethane spoked wheel. AKRON—For the record, Michelin's Steve Cron isn't a big fan of the name given to the product that has defined much of his 30-year career in the tire industry. That product is the Tweel, the tire maker's easily recognizable product that combines a non-pneumatic tire with a polyurethane spoked wheel. $AKRON—For the record, Michelin's Steve Cron isn't a big fan of the name given to the product that has defined much of his 30-year career in the tire industry. That product is the Tweel, the tire maker's easily recognizable product that combines a non-pneumatic tire with a polyurethane spoked wheel.
Old Dana taps the fountain of youth
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MAUMEE, Ohio—With little fanfare this year, one of the global auto industry's oldest suppliers began repositioning itself for a business of the future. Dana Inc. has made two key...
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MAUMEE, Ohio—With little fanfare this year, one of the global auto industry's oldest suppliers began repositioning itself for a business of the future. MAUMEE, Ohio—With little fanfare this year, one of the global auto industry's oldest suppliers began repositioning itself for a business of the future. $MAUMEE, Ohio—With little fanfare this year, one of the global auto industry's oldest suppliers began repositioning itself for a business of the future.
Kent Elastomer to expand headquarters
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KENT, Ohio—Kent Elastomer Products Inc. is expanding its headquarters to accommodate its growing work force.The firm broke ground on an extension to the office area of its Kent facility,...
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KENT, Ohio—Kent Elastomer Products is expanding its headquarters to accommodate its growing work force. KENT, Ohio—Kent Elastomer Products is expanding its headquarters to accommodate its growing work force. $KENT, Ohio—Kent Elastomer Products is expanding its headquarters to accommodate its growing work force.
Private equity firm KKR set to acquire Minnesota Rubber & Plastics
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MINNEAPOLIS—Norwest Equity Partners has agreed to sell Quadion L.L.C., which does business as Minnesota Rubber & Plastics, to global investment firm KKR & Co. L.P. Terms of the...
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MINNEAPOLIS—Norwest Equity Partners has agreed to sell Quadion, which does business as Minnesota Rubber & Plastics, to global investment firm KKR. MINNEAPOLIS—Norwest Equity Partners has agreed to sell Quadion, which does business as Minnesota Rubber & Plastics, to global investment firm KKR. $ MINNEAPOLIS—Norwest Equity Partners has agreed to sell Quadion, which does business as Minnesota Rubber & Plastics, to global investment firm KKR.
Video: Miller calls Louisville Rubber Division meeting a success LOUISVILLE, Ky.—This week's ACS Rubber Division's International Elastomer Conference has been a success on all levels, according to Executive Director Ed Miller. LOUISVILLE, Ky.—This week's ACS Rubber Division's International Elastomer Conference has been a success on all levels, according to Executive Director Ed Miller. $LOUISVILLE, Ky.—This week's ACS Rubber Division's International Elastomer Conference has been a success on all levels, according to Executive Director Ed Miller.
Digital Edition
Digital Edition
Published on January 1, 2007

How To Ensure that a Manufactured Latex Product has the Lowest Practicable Allergen Levels

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Date Published January 1, 2007
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This Report has been authored by:Timo Palosuo at Finland National Public Health Institute

Immediate allergic reactions to natural rubber latex (NRL) proteins continue to be an important medical and occupational health problem. Attempts at minimizing protein and allergen concentration in NRL gloves to prevent sensitization and the development clinical allergy to NRL are acknowledged as a goal of mutual interest for rubber manufacturers and regulatory health authorities. Total protein determination has been widely used for the indirect estimation of allergen content in NRL products but consensus exists today that allergen-specific assays that are specific, of high sensitivity and reproducibility and can be properly standardized, would provide much more reliable information. We quantified four NRL allergens (Hev b 1, Hev b 3, Hev b 5 and Hev b 6.02) in 208 glove brands by a capture enzyme immunoassay (FITKit®). The results were compared with those from a skin prick test-validated human IgE-based ELISA-inhibition method that has been considered as the “golden standard” for demonstration of allergenicity of rubber products. A high overall correlation ( r=0.87, 95% CI 0.83 to 0.90) emerged between the sum values of the four allergens(µg/g glove) and IgE-ELISA inhibition. The sum, when set at 0.15 µg/g discriminated “low allergenic” (< 10 AU/ml) from “moderate to high allergenic” (>10 AU/ml) gloves at a sensitivity of 0.93 (95% CI 0.85 to 0.98) and specificity of 0.90 (95% CI 0.83 to 0.94). In conclusion, the allergenic potential of medical gloves could be assessed with remarkably high specificity and sensitivity. For the four allergen sum test we set up a cut-off level (0.15 µg/g) below which virtually all gloves can be considered as low allergenic. Although it is still not possible to make claims of safety, the specific allergen tests will be a very useful practical guide to personnel responsible for glove purchasing in hospitals and health care centers and also to conventional glove users to support their glove selection policies. 
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